amillaria mellea powder
Armillarisin A
CAS: 53696-74-5
Molecular Formula: C12H10O5
amillaria mellea powder - Names and Identifiers
amillaria mellea powder - Physico-chemical Properties
| Molecular Formula | C12H10O5 |
| Molar Mass | 234.2 |
| Density | 1.476±0.06 g/cm3(Predicted) |
| Melting Point | 250-255°C |
| Boling Point | 565.0±50.0 °C(Predicted) |
| Flash Point | 227.2°C |
| Vapor Presure | 1.32E-13mmHg at 25°C |
| Appearance | Brown or tan powder |
| pKa | 7.10±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.642 |
| MDL | MFCD01662561 |
| Physical and Chemical Properties | Melting point 250-255°C |
| Use | Hepatobiliary medicine, for Acute Biliary tract infection, viral hepatitis, chronic gastritis, etc |
amillaria mellea powder - Reference Information
| overview | acute biliary tract infection is a common clinical disease in digestive department. during the attack, common patients complicated with jaundice and liver function damage generally improve at the same time as biliary tract infection, liver function and jaundice of patients can also be gradually improved. however, the symptoms and signs of biliary tract infection have been effectively controlled in many patients. reexamination of liver function still shows how jaundice index and transaminase rise can be effectively controlled while biliary tract infection is effectively controlled, effective improvement of liver function and jaundice index of patients remains to be studied. Leucocin A is a new coumarin compound, which is one of the effective ingredients extracted from Pseudomonas. Studies have shown that Arillarisin A injection can promote the secretion of bile by liver cells, relax the sphincter of Oddi, regulate the pressure of the biliary system, and promote the excretion of biliary contents, thereby reducing intrahepatic cholestasis, and it can also regulate and Promote immune function, enhance phagocytic function, improve liver cell edema and fibrous tissue proliferation, promote the repair and regeneration of damaged liver cells, thereby eliminating inflammation of the biliary tract and gastrointestinal tract, and further improving liver function, it is helpful to clear endotoxemia, thus reducing cholestasis caused by endotoxemia. Arillarisin A injection can shorten the course of acute biliary tract infection and the duration of jaundice, significantly improve liver function indicators, and quickly improve clinical symptoms without obvious side effects. It is worthy of clinical promotion. Leucocin A, extracted from Leucococcus (I. e. Pseudomonas of the genus Cyclobacterium), the chemical name is 3-acetyl-5-hydroxymethyl-7-hydroxycoumarin, which is a new Coumarin compound is one of the effective ingredients extracted from Pseudomonas, and can also be synthesized artificially. Studies have shown that Arillarisin A injection can promote bile secretion, has a significant antispasmodic effect on the sphincter of the biliary tract, enhances immune function and promotes phagocytosis of phagocytes, promotes immune function, improves liver cell edema, necrosis and liver fibrous tissue proliferation, Promote the repair and regeneration of damaged liver cells, improve protein metabolism, improve protein metabolism, reduce jaundice, regulate liver function, reduce the tension of the duodenum, regulate the pressure of the biliary system, and promote the excretion of biliary contents, regulate and promote immune function and enhance the effect of phages to produce antibacterial effects, and can improve protein metabolism, regulate liver function, eliminate inflammation of the biliary tract and gastrointestinal tract, and improve liver function, which can help eliminate endotoxemia and reduce cholestasis caused by endotoxemia. Clinically used in the treatment of acute biliary tract infection, the effect is slightly similar to that of antibiotics, but the effect of treating obstructive type is not significant. It can also be used to treat viral hepatitis. In addition, it can also be used to treat chronic gastritis. |
| traits | leucin a is yellow or light yellow rectangular crystalline powder. Insoluble in water, very slightly soluble in ethanol and methanol. Melting point 253~255 ℃. Fig. 1 is the structural formula |
| pharmacological effects and uses | this product, also known as pseudocyclin a, is a new coumarin compound, which is an effective ingredient extracted from pseudocyclonia. It can promote bile secretion, relax the sphincter of the bile duct, reduce the tension of gastrointestinal smooth muscle, regulate the pressure of the bile duct system, promote the excretion of bile duct contents, regulate and promote immune function, and enhance the effect of phagocytes. It can improve protein metabolism and regulate liver function. It is suitable for the treatment of acute and chronic cholecystitis, other bile duct diseases complicated with acute infection, viral hepatitis, liver function damage, and the treatment of chronic gastritis and enteritis. The effect on acute bile duct infection with obstruction is not significant. |
| hydroxymethyl coumarin | hydroxymethyl coumarin alias: dantong, shudanning, Himecol, Cantabiline, clinically used for cholecystitis, biliary tract infection, cholelithiasis, gallbladder postoperative syndrome, is a coumarin derivative, has a selective relaxation effect on the sphincter of Oddi, and can promote the long-lasting discharge of bile. And has strong antispasmodic and analgesic effects. Clinical observations have proved that this product has obvious choleretic effect, strong analgesic effect (stronger than atropine), and has the effects of relieving biliary sphincter spasm, increasing bile secretion, strengthening gallbladder contraction and bacteriostasis, etc., which is conducive to stone discharge, and has a certain stone removal effect on total bile duct stones. In addition, in some patients with elevated alanine aminotransferase, the enzyme returned to normal with the elimination of inflammation after taking the medicine. Patients with obstructive or infectious jaundice should be used with caution. Some patients have dizziness, abdominal distension, chest tightness, rash, diarrhea and other adverse reactions, which disappear after stopping the drug. High doses can cause excessive bile secretion and diarrhea. |
| pharmacodynamics | this drug is a bile water secretion promoter. Its choleretic effect is the same as that of equal doses of dehydrocholic acid, but the duration is short. In addition, it can obviously relax the sphincter of Oddi, which has a choleretic effect. This drug may also promote immune function and enhance phagocytosis of phagocytes. It works quickly. |
| use | treat dizziness, neurasthenia, insomnia, tinnitus, limb numbness and epilepsy caused by different reasons. Hepatobiliary drugs are used for acute biliary tract infection, viral hepatitis, chronic gastritis, etc. |
| production method | slant spore [shake flask culture] →[25-26 ℃, 15-20d] primary shake flask seed [shake flask culture] →[25-26℃, 5-6d] secondary shake flask seed [seed tank culture, proper ventilation] →[26-28℃, 5-6d] primary seed culture solution [seed tank culture] →[26-28℃, 5-6d] secondary seed culture broth [fermentation, proper aeration] →[26-27 ℃,7-9d] fermentation broth → mycelium is dried, filtrate is concentrated and dried and combined [drying, milling] → Dellichitis powder. |
Last Update：2024-04-09 21:11:58
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Product Name: Armillarisin A Visit Supplier Webpage Request for quotation
CAS: 53696-74-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 53696-74-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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